Ixodes scapularis saliva components that elicit responses associated with acquired tick-resistance
نویسندگان
چکیده
منابع مشابه
Identification and Characterization of Ixodes scapularis Antigens That Elicit Tick Immunity Using Yeast Surface Display
Repeated exposure of rabbits and other animals to ticks results in acquired resistance or immunity to subsequent tick bites and is partially elicited by antibodies directed against tick antigens. In this study we demonstrate the utility of a yeast surface display approach to identify tick salivary antigens that react with tick-immune serum. We constructed an Ixodes scapularis nymphal salivary g...
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BACKGROUND Ticks act as vectors for a large number of different pathogens, perhaps most notably Borrelia burgdorferi, the causative agent of Lyme disease. The most prominent tick vector in the United States is the blacklegged tick, Ixodes scapularis. Tick bites are of special public health concern since there are no vaccines available against most tick-transmitted pathogens. Based on the observ...
متن کاملIxodes scapularis Tick Saliva Proteins Sequentially Secreted Every 24 h during Blood Feeding
Ixodes scapularis is the most medically important tick species and transmits five of the 14 reportable human tick borne disease (TBD) agents in the USA. This study describes LC-MS/MS identification of 582 tick- and 83 rabbit proteins in saliva of I. scapularis ticks that fed for 24, 48, 72, 96, and 120 h, as well as engorged but not detached (BD), and spontaneously detached (SD). The 582 tick p...
متن کاملA preliminary linkage map of the hard tick, Ixodes scapularis.
A linkage map of the Ixodes scapularis genome was constructed, based upon segregation amongst 127 loci. These included 84 random amplified polymorphic DNA (RAPD) markers, 32 Sequence-Tagged RAPD (STAR) markers, 5 cDNAs, and 5 microsatellites in 232 F1 intercross progeny from a single, field-collected P1 female. A preliminary linkage map of 616 cM was generated across 14 linkage groups with one ...
متن کاملProposal for Sequencing the Genome of the Tick, Ixodes scapularis
This proposal represents the cooperative efforts of the international tick research community to develop the first large scale genomic analysis of a medically significant tick, namely Ixodes scapularis. Ticks transmit the greatest variety of human and animal pathogens of any arthropod vector and are second only to mosquitoes as vectors of human disease (Fivaz et al., 1992; Sonenshine and Mather...
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ژورنال
عنوان ژورنال: Ticks and Tick-borne Diseases
سال: 2020
ISSN: 1877-959X
DOI: 10.1016/j.ttbdis.2019.101369